Environmental or self-antigens and homotypic interactions set off BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts within the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions,... https://williamv742nwc9.wikiconverse.com/user