Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts through the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have recognized recurrent mutations in genes regulating tumor cell-microenvironment interactio... https://giordanos753rah1.laowaiblog.com/profile