You will find a release of norepinephrine from your descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lessen afferent agony transmission and develop analgesia. Therefore, drugs like clonidine that target alpha-two receptors can impact the transmission of ache. Clonidine is dispersed in breast milk; https://www.proleviate.com/post/the-new-pain-killer-conolidine