No refrigeration is important, so keep it in a convenient place in your case. These probiotics are microorganisms effective for your dog’s digestive tract, that means this spray is all-all-natural. These microorganisms do the job by improving The nice bacteria that are previously current while in the dog’s digestive tract. https://www.amazon.com/Healthy-Treatz-Probiotic-Chews-Dogs/dp/B07VCGNM6X